Mechanism of Action Inhibits the inflammatory response to mechanical, chemical, or immunologic agents Corticosteroids inhibit edema, fibrin deposition, capillary dilatation, and migration of leukocytes and phagocytes in the acute inflammatory response Dexamethasone reduces the irritation, redness, burning, and swelling of eye caused by chemicals, heat, radiation, infection, allergy, or foreign bodies in the eye. Mechanism of Action Decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability; suppresses normal immune response Pharmacodynamics/Kinetics Dexamethasone is a type of corticosteroid medication. It is used in the treatment of many conditions, including rheumatic problems , a number of skin diseases , severe allergies , asthma , chronic obstructive lung disease , croup , brain swelling , and along with antibiotics in tuberculosis. [1] Pharmacology and mechanism of action Corticosteroid. Anti-inflammatory and immunosuppressive effects of dexamethasone are approximately 30 times more potent than cortisol. Dexamethasone: Following ophthalmic administration, dexamethasone is absorbed through the aqueous humor, with only minimal systemic absorption occurring. Clinical evidence of absorption usually does not occur because topical ophthalmic corticosteroid doses are less than when the drugs are given systemically. The onset of action typically occurs within a few days, but it can take as long as 7. The mechanism of action of dexamethasone is as a Corticosteroid Hormone Receptor Agonist. from FDA Pharm Classes Dexamethasone is a synthetic adrenal corticosteroid with potent anti-inflammatory properties. Dexamethasone ophthalmic (for the eyes) is a steroid medicine used to treat eye inflammation caused by allergies, shingles (herpes zoster), severe acne, iritis, uveitis, eye injury, radiation, chemical burns, or certain other conditions. Dexamethasone is used to treat inflammatory conditions such as allergies, skin conditions, ulcerative colitis, arthritis and breathing disorders. Includes dexamethasone side effects, interactions and indications.